2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. NEDD8-activating Enzyme
  5. NEDD8-activating Enzyme Activator

NEDD8-activating Enzyme Activator

NEDD8-activating Enzyme Activator (1):

Cat. No. Product Name Effect Purity
  • HY-185011
    AM9053
    		Activator 98.36%
    AM9053 is a selective, effective and slowly reversible inhibitor of N-acyl ethanolamine acid amidease (NAAA) (IC50 = 30 nM). The effect of AM9053 on FAAH activity is limited (IC50 > 100 nM). AM9053 inhibits the proliferation of colorectal cancer cells by activating the PPAR-α and TRPV1 dependent mechanisms and induces S-phase cell cycle arrest. AM9053 alleviates intestinal fibrosis by regulating macrophage activity and inhibiting the IL-23 signaling pathway. AM9053 leads to an increase in NAE levels, especially PEA and OEA. AM9053 can be used for the study of colorectal cancer and intestinal fibrosis.